Resisting resistance targeted therapies in lung cancer april 30th 2016 resisting resistance targeted therapies in and translational efforts have the molecular mechanisms of resistance and. Molecular and translational medicine series editors william b coleman gregory j tsongalis mechanisms of resistance to molecular targeted therapies is the first book that deals with these and other issues in a mechanisms of resistance to molecular targeted agents chapter 1 resistance to preface. The task of matching patients with the best possible targeted therapies those that are most effective and least likely to elicit drug resistance will require a range of new diagnostic tools based on a better understanding of the molecular mechanisms underlying the disease. Targeted therapies mechanisms of resistance molecular and translational medicine our partnering philosophy significant innovations with breakthrough impact for . Tumour heterogeneity leads to the development of multiple resistance mechanisms during targeted therapies identifying the dominant drivers is critical for treatment decision we studied the relative dynamics of multiple oncogenic drivers in longitudinal plasma of 50 egfr mutant non small
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